Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12p40
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
129/Sv x C57BL/6J
Level of backcrossing:
Backcrossed for 5 generations
Experimental treatment group (EG):
IL-12p40 -/- + rIL-12
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
Anemia
Pathology (EG):
Anemia
Parasitemia (EG vs Con):
Increased recrudescences, but less than without rIL-12
Additional phenotypes (EG vs Con):
Similar serum levels of parasite-specific total Ig, IgM and IgG2a, ↓ IgG1; similar protection against challenge infection; similar IgG2a, IgG3, IgG1 and IgG2b 7 days after challenge infection
Refs:
Su et al., 2002, J Immunol
Hyperlink: