Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12p40
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
Backcrossed for 5 generations
Experimental treatment group (EG):
IL-12 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
N.I.
Pathology (Con):
Liver pathology
Pathology (EG):
No liverpathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ GPT (ALT) serum levels; no liver injury; similar infiltration of lymphocytes in liver
Refs:
Adachi et al., 2001, J Immunol
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