Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/J
Experimental treatment group (EG):
rIL-10
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (38.6 %)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Prolonged survival (days-weeks); no neurological symptoms; similar TNF-a
Refs:
Kossodo et al., 1997, Immunology
Hyperlink: