IL-10/IFN-g

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IL-10/IFN-g
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
129/Sv x C57BL/6
Level of backcrossing: 
Mixed background (50%)
Experimental treatment group (EG): 
IL-10-/- x IFN-gR-/-
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
Anemia
Pathology (EG): 
Anemia
Parasitemia (EG vs Con): 
Prolonged acute parasitemia and prominent second peak
Additional phenotypes (EG vs Con): 
Similar hypothermia, hypoglycemia, weight loss and plasma TNF-a compared to IL-10-/- mice
Refs: 
Li et al., 1999, Infect Immun