Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10/IFN-g
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
129/Sv x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
IL-10-/- x IFN-gR-/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
Anemia
Pathology (EG):
Anemia
Parasitemia (EG vs Con):
Prolonged acute parasitemia and prominent second peak
Additional phenotypes (EG vs Con):
Similar hypothermia, hypoglycemia, weight loss and plasma TNF-a compared to IL-10-/- mice
Refs:
Li et al., 1999, Infect Immun
Hyperlink: