Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10/CD25
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IL-10 -/- + anti-CD25
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Delayed mortality (1-2 days); similar neurologic symptoms
Refs:
Amante et al., 2007, Am J Pathol
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