Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10/TNF-a
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^4
Mouse genetic background (Con):
IL-10 -/-
Level of backcrossing:
Backcrossed for at least 8 generations
Experimental treatment group (EG):
anti-TNF-a
Lethal infection (Con):
♀ 70 %
Lethal infection (EG):
no
Pathology (Con):
CM (♀ 70 %)
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ cerebral edema and hemorrhages (50 %)
Refs:
Sanni et al., 2004, Infect Immun
Hyperlink: