Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for at least 8 generations
Experimental treatment group (EG):
IL-10 -/-
Lethal infection (Con):
no
Lethal infection (EG):
♀ 70 %
Pathology (Con):
Anemia
Pathology (EG):
CM (♀ 70 %)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ parasite sequestration; cerebral edema and hemorrhages (CM?)
Refs:
Sanni et al., 2004, Infect Immun
Hyperlink: