Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10/TGF-b
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
IL-10 -/-
Level of backcrossing:
Backcrossed for 7 generations
Experimental treatment group (EG):
anti-TGF-b
Lethal infection (Con):
♀ 66 %
Lethal infection (EG):
♀ yes (100%)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ anemia and hypoglycemia, similar hypothermia and weight loss; ↑ plasma IFN-g and TNF-a
Refs:
Li et al., 2003, Infect Immun
Hyperlink: