Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10/TNF-a
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
IL-10 -/-
Level of backcrossing:
Backcrossed for 7 generations
Experimental treatment group (EG):
anti-TNF-a
Lethal infection (Con):
♀ 66 %
Lethal infection (EG):
♀ no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased recrudescences
Additional phenotypes (EG vs Con):
↓ hypothermia, anemia, weight loss and similar hypoglycemia; similar plasma IFN-g
Refs:
Li et al., 2003, Infect Immun
Hyperlink: