Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 7 generations
Experimental treatment group (EG):
IL-10 -/-
Lethal infection (Con):
no
Lethal infection (EG):
♀ 66 %
Pathology (Con):
Anemia
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ mortality; surviving mice had ↓ hypothermia and hypoglycaemia, similar anemia and weight loss; ↑ serum TGF-b
Refs:
Li et al., 2003, Infect Immun
Hyperlink: