Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 7 generations
Experimental treatment group (EG):
IL-10 -/-
Lethal infection (Con):
no
Lethal infection (EG):
♀ 30 %; ♂ no
Pathology (Con):
Anemia
Pathology (EG):
Anemia
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ mortality;↑ hypothermia, hypoglycemia and weight loss in ♀; ↑ plasma TNF-a and IFN-g; ↑ TNF-a, IFN-g, IL-12p40 and NOS2 mRNA in spleen
Refs:
Li et al., 1999, Infect Immun
Hyperlink: