IL-10

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IL-10
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
129/Sv x C57BL/6
Level of backcrossing: 
Mixed background (50%)
Experimental treatment group (EG): 
IL-10 -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
♀ 50 %; ♂ no
Pathology (Con): 
Anemia
Pathology (EG): 
Anemia
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
↑ mortality;↑ hypothermia, hypoglycemia and weight loss in ♀
Refs: 
Li et al., 1999, Infect Immun