Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IL-10 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
↑ Liver pathology
Parasitemia (EG vs Con):
Decreased
Additional phenotypes (EG vs Con):
Similar weight loss (↓ compared to IL-27R -/- mice); ↑ liverpathology (similar compared to IL-27R -/- mice); ↑ numbers of total splenic CD4+ T cells and similar numbers of liver-infiltrating CD4+ T cells 14 days p.i. (↑ numbers of total splenic CD4+ T cells and ↓ numbers of liver-infiltrating CD4+ T cells compared to IL-27R -/- mice)
Refs:
Findlay et al., 2010; J immunol
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