Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-4Ra
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
sporozoites (400 or 800) or pRBC (10^2, 10^4 or 10^6)
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
IL-4Ra -/-
Lethal infection (Con):
yes
Lethal infection (EG):
40% (infection with 400 sporozoites); yes (infection with pRBC or 800 sporozoites)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
No detectable parasitemia (infection with 400 sporozoites) or similar (infection with pRBC or 400 sporozoites)
Additional phenotypes (EG vs Con):
Surviving mice after infection with 400 sporozoites:↑ IFN-g-producing NK cells and NOS2 expression (mRNA and protein) in the liver
Refs:
Saeftel et al., 2004, Infect Immun
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