Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-4/NK cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
400 sporozoites
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Backcrossed for 6 generations
Experimental treatment group (EG):
IL-4 -/- + anti-asialo GM1
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased compared to anti-asialo GM1 treated WT BALB/c mice
Additional phenotypes (EG vs Con):
Similar IFN-g protein in the liver 3 days p.i. compared to untreated WT and ↓ compared to untreated IL-4 -/-
Refs:
Saeftel et al., 2004, Infect Immun
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