IL-4/NK cells

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IL-4/NK cells
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
400 sporozoites
Mouse genetic background (Con): 
BALB/c
Level of backcrossing: 
Backcrossed for 6 generations
Experimental treatment group (EG): 
IL-4 -/- + anti-asialo GM1
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Decreased compared to anti-asialo GM1 treated WT BALB/c mice
Additional phenotypes (EG vs Con): 
Similar IFN-g protein in the liver 3 days p.i. compared to untreated WT and ↓ compared to untreated IL-4 -/-
Refs: 
Saeftel et al., 2004, Infect Immun