Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-4/NOS2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
400 sporozoites
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Backcrossed for 6 generations
Experimental treatment group (EG):
IL-4 -/- + NOS2 inhibitor
Lethal infection (Con):
50%
Lethal infection (EG):
80-100%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased compared to NOS2 inhibitor treated WT BALB/c mice
Additional phenotypes (EG vs Con):
N.I.
Refs:
Saeftel et al., 2004, Infect Immun
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