Molecular group:
Cytokines and receptors
Molecule/Cell:
GM-CSF
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
129/Ola x C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
GM-CSF -/-
Lethal infection (Con):
no
Lethal infection (EG):
♂ 75 %; ♀ 46 %
Pathology (Con):
Anemia
Pathology (EG):
Anemia
Parasitemia (EG vs Con):
Increased peak and increased recrudescences
Additional phenotypes (EG vs Con):
↓ splenomegaly; ↓ leukocytosis (↓ number of macrophages, lymphocytes and similar granulocytes); similar anemia and erythropoiesis; ↑ serum TNF-a and IFN-g (↑ serum IFN-g also in uninfected KO mice compared to uninfected WT mice)
Refs:
Riopel et al., 2001, Infect Immun
Hyperlink: