Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-3/GM-CSF
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-IL-3 and anti-GM-CSF
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (13%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); no neurological symptoms; ↓ serum TNF-a; ↓ macrophage infiltration of white pulp (spleen)
Refs:
Grau et al., 1988, J Exp Med
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