Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-2/gd T cell
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
DBA/2
Experimental treatment group (EG):
rIL-2 + anti -gd-T cell
Lethal infection (Con):
no
Lethal infection (EG):
71%
Pathology (Con):
None
Pathology (EG):
CM (71%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Anti-gd treatment delayed (2-3 weeks) or abrogated (2/7 mice stayed healthy until the last day of observation) cerebral symptoms compared to rIL-2 treatment alone
Refs:
Haque et al., 2001, Am J Pathol
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