Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-2
Plasmodium strain:
Plasmodium yoelii 17XNL
pRBC infection titer:
10^6
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
rIL-2
Lethal infection (Con):
no
Lethal infection (EG):
70%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased peak
Additional phenotypes (EG vs Con):
Induction of IL-2, IFN-g, IL-6 and IL-10 mRNA expression in splenic cells; ↑ CD3 or ConA-induced lymphocyte proliferation
Refs:
Lucas et al., 1996, C R Acad Sci III
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