Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-2
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
DBA/2
Experimental treatment group (EG):
rIL-2
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
None
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Splenocytes 3 days p.i.: ↓ IFN-g , ↑ NO and IL-10; splenocytes 6 days p.i.: similar IFN-g and IL-10, ↑ NO; cerebral accumulation of pRBCs and CD25+ ICAM-1+ T cells (mostly gd T cells)
Refs:
Haque et al., 2001, Am J Pathol
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