Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-2/B cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
129 x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
IL-2 -/- x m-MT
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed peak
Additional phenotypes (EG vs Con):
↑ % of Mac-1+ and CD4+ cells and ↓ % of CD8, gd and B cells in the spleen
Refs:
Seixas et al., 2002, Parasite Immunol
Hyperlink: