IL-2

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IL-2
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
129 x C57BL/6
Level of backcrossing: 
Mixed background (50%)
Experimental treatment group (EG): 
IL-2 -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
25%
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Delayed peak and delayed clearance
Additional phenotypes (EG vs Con): 
↑ Mac-1+, ↓ CD3+ (especially CD8+ and gd+) and B cells in the spleen
Refs: 
Seixas et al., 2002, Parasite Immunol