Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-2
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
129 x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
IL-2 -/-
Lethal infection (Con):
no
Lethal infection (EG):
25%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed peak and delayed clearance
Additional phenotypes (EG vs Con):
↑ Mac-1+, ↓ CD3+ (especially CD8+ and gd+) and B cells in the spleen
Refs:
Seixas et al., 2002, Parasite Immunol
Hyperlink: