Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-1a
Plasmodium strain:
Plasmodium berghei K173
pRBC infection titer:
10^3
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
rIL-1a
Lethal infection (Con):
yes
Lethal infection (EG):
N.I.
Pathology (Con):
CM (100%)
Pathology (EG):
CM (22%)
Parasitemia (EG vs Con):
Delayed
Additional phenotypes (EG vs Con):
↓ CM incidence only when administered for 6 consecutive days and dose-dependent; no cerebral hemorrhages; no decrease in body temperature; no differences in erythropoiesis
Refs:
Curfs et al., 1990, J Exp Med
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