Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-gR
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IFN-gR -/-
Lethal infection (Con):
No
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased on day 9
Additional phenotypes (EG vs Con):
↓ sequestration in livers (day 5 and day 9 p.i.), but not in spleen or lungs; ↓ serum ALT levels; similar numbers of IFN-g+ lymphocytes in the lungs 9 days p.i.; similar IgM and albumin levels in BAL fluid; similar tubular dilatation, plasma creatinine levels and plasma urea levels
Refs:
Brugat et al., 2013, Cell Microbiol
Hyperlink: