Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
IRF8
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x C3H/HeJ
Level of backcrossing:
Mixed background
Experimental treatment group (EG):
IRF8 +/- [BXH2 x B6]F1
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (~50%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No infiltration of CD4+ and CD8+ T cells, CD11b+Ly6G+ granulocytes or monocytes in the brain; similar numbers of CD11b+Ly6G+, CD11b+F4/80+, Ly6C-CD11b+CD11c+MHC-II+, and CD4+ T cells, and ↓ numbers of CD8+ T cells in the spleen at day 6 p.i.; ↓ serum IL-12p40 and IFN-g levels; ↓ ex vivo production of IL-12p40 and IFN-g by splenocytes from day 6 infected mice
Refs:
Berghout et al., 2013, PLoS Pathog
Hyperlink: