Molecular group:
Immune cells
Molecule/Cell:
Platelets
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
+ anti-platelet (anti-GPIb) (day -1) + serum amyloid P (rSAP)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Delayed mortality (days) compared to the platelet depleted mice without rSAP treatment
Refs:
Aggrey et al., 2013, J Immunol
Hyperlink: