Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
IRF-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IRF-1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (~75%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar numbers of CD11b+Ly6G+, Ly6C-CD11b+CD11c+MHC-II+, and CD4+ T cells, ↓ numbers of CD8+ T cells, and slightly but significantly ↑ numbers of CD11b+F4/80+ cells in the spleen at day 6 p.i.; similar serum IL-12p40 and ↓ IFN-g levels; ↓ ex vivo production of IL-12p40 by splenocytes from day 6 infected mice
Refs:
Berghout et al., 2013, PLoS Pathog
Hyperlink: