Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
N.I.
Organ:
Brain (PM)-IHC
Population:
Malawi
Transmission:
Stable
Adult/Pediatric:
Pediatric (Adult)
CM vs NM-CNS:
=
CM vs NM-NCNS:
>
Patient number:
14
Additional differences:
TNF-a mRNA present in all CM cases, no TNF-a mRNA in NM-CNS, and in only 1 NM-NCNS case whereas TNF-a protein staining was found in all CM and NM-CNS brains but not in NM-NCNS brains; expressed by splenic MF from CM patients; + correlation with TGF-b and IL-1b
Refs:
Brown et al., 1999, J Infect Dis
Hyperlink: