Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium falciparum
Organ:
Plasma
Population:
The Gambia
Transmission:
Stable
Adult/Pediatric:
Pediatric
SM† vs SM:
>
Patient number:
115
Additional differences:
Levels did not significantly change during the first 24h; logistic regression indicated TNF-a levels > 300 pg/mL as an independently predictive of fatal outcome; + correlation with admission venous lactate concentrations, and blood IL-1a; - correlation with blood glucose concentration (not independently of hyperlactatemia)
Refs:
Krishna et al., 1994, Trans R Soc Trop Med Hyg
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