Molecular group:
Immune cells
Molecule/Cell:
Platelets
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
+ anti-platelet (anti-GPIb) or platelet inhibitor (Clopidogrel) (day -1)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80-100%)
Pathology (EG):
CM (80-100%)
Parasitemia (EG vs Con):
Increased on day 5
Additional phenotypes (EG vs Con):
↓ plasma concentrations of serum amyloids A and P and IL-1b
Refs:
Aggrey et al., 2013, J Immunol
Hyperlink: