Molecular group:
Immune cells
Molecule/Cell:
Lymphocytes
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
RAG1-/-
Lethal infection (Con):
No
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased on day 9
Additional phenotypes (EG vs Con):
↓ sequestration in livers (day 5 and day 9 p.i.) and spleen (day 5 p.i.), but not in the lungs; ↓ serum ALT levels; ; similar albumin levels in BAL fluid; similar tubular dilatation and plasma creatinine levels and ↑ plasma urea levels
Refs:
Brugat et al., 2013, Cell Microbiol
Hyperlink: