Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
LMP7
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
2,5 x 10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
LMP7 -/-
Lethal infection (Con):
yes (100%)
Lethal infection (EG):
yes (40%)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Improved clearance
Additional phenotypes (EG vs Con):
Similar proportion of CD69+CD4+ and CD69+CD8+ T cells, similar proportion of IFN-g+CD4+ T cells, ↓ in IFN-g+CD8+ T cells, similar splenic IFN-g mRNA, ↓ DC activation, similar phagocytosis capacity of macrophages, ↑ susceptibility of iRBC to be phagoyctosed
Refs:
Duan et al., 2013, PLoS One
Hyperlink: