IRF8

Molecular group: 
Signal transduction and intracellular danger sensors
Molecule/Cell: 
IRF8
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6 x C3H/HeJ
Level of backcrossing: 
Mixed background
Experimental treatment group (EG): 
IRF8 -/- (BXH2)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
No CM
Parasitemia (EG vs Con): 
Similar until d9, followed by rapid increase
Additional phenotypes (EG vs Con): 
No BBB leakage; no infiltration of CD4+ and CD8+ T cells, CD11b+Ly6G+ granulocytes or monocytes in the brain; ↑ numbers of CD11b+Ly6G+ and CD11b+F4/80+ cells, ↓ numbers of Ly6C-CD11b+CD11c+MHC-II+ and CD8+ T cells, and similar numbers of CD4+ T cells in the spleen at day 6 p.i.; ↓ serum IL-12p40 and IFN-g levels; ↓ ex vivo production of IL-12p40 and IFN-g by splenocytes from day 6 infected mice
Refs: 
Berghout et al., 2013, PLoS Pathog