Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-10
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IL-10 -/-
Lethal infection (Con):
No
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ sequestration in the spleen (day 9 p.i.) and in the liver (day 5 and day 9 p.i. although not significantly), but not in the lungs; similar serum ALT levels; ↑ numbers of IFN-g+ lymphocytes in the lungs 9 days p.i.; ↑ IgM and albumin levels in BAL fluid; ↑ tubular dilatation, plasma creatinine levels and plasma urea levels
Refs:
Brugat et al., 2013, Cell Microbiol
Hyperlink: