Molecular group:
Cytokines and receptors
Molecule/Cell:
IFNaR1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
IFNaR1 -/-
Level of backcrossing:
98.7-99.36% C57BL/6 background outside of the congenic region
Experimental treatment group (EG):
+ adoptive transfer of splenic CD8+ cells from IFNaR1-/- mice that had recieved irradiated pRBCs
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
No CM
Pathology (EG):
CM (~25%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
N.I.
Refs:
Ball et al., 2013, J Immunol
Hyperlink: