Molecular group:
Cytokines and receptors
Molecule/Cell:
IFNaR1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
IFNaR1 -/-
Level of backcrossing:
98.7-99.36% C57BL/6 background outside of the congenic region
Experimental treatment group (EG):
+ adoptive transfer of splenocytes depleted of CD8+ cells from C57BL/6 mice that had recieved irradiated pRBCs
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
No CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No BBB leakage (similar compared to infected IFNaR1-/- that not recieved cells); CD8+, CD8+GrB+, and CD8+IFN-g+ cells were found in the brain
Refs:
Ball et al., 2013, J Immunol
Hyperlink: