IFNaR1

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IFNaR1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
IFNaR1 -/-
Level of backcrossing: 
98.7-99.36% C57BL/6 background outside of the congenic region
Experimental treatment group (EG): 
+ adoptive transfer of splenocytes depleted of CD8+ cells from C57BL/6 mice that had recieved irradiated pRBCs
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
No CM
Pathology (EG): 
No CM
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
No BBB leakage (similar compared to infected IFNaR1-/- that not recieved cells); CD8+, CD8+GrB+, and CD8+IFN-g+ cells were found in the brain
Refs: 
Ball et al., 2013, J Immunol