Molecular group:
Cytokines and receptors
Molecule/Cell:
IFNaR1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
98.7-99.36% C57BL/6 background outside of the congenic region
Experimental treatment group (EG):
IFNaR1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (~90%)
Pathology (EG):
CM (~25%)
Parasitemia (EG vs Con):
Increased on day 6-7
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks); no neurological symptoms; no BBB leakage; less intravascular accumulation of mononuclear cells; no endothelial cell disruption or hemorrhagic lesions; similar parasite accumulation and CD3 expression in the brain; delayed kinetics of TNF and IL-10 mRNA expression in the brain; ↓ numbers of CD8+, CD8+GrB+, and CD8+IFN-g+ cells in the spleen at baseline in uninfected mice, similar numbers in the spleen at day 5 p.i., and ↓ numbers in the brain at day 6 p.i.
Refs:
Ball et al., 2013, J Immunol
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