Molecular group:
Cytokines and receptors
Molecule/Cell:
HMGB1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
+ anti-HMGB1
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (95%)
Pathology (EG):
CM (75%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar mortality; similar plasma levels of TNF, IL-12, IFN-g, IL-10 and CCL2 (MCP-1)
Refs:
Higgins et al., 2013, Malar J
Hyperlink: