HMGB1

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
HMGB1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
+ anti-HMGB1
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (95%)
Pathology (EG): 
CM (75%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar mortality; similar plasma levels of TNF, IL-12, IFN-g, IL-10 and CCL2 (MCP-1)
Refs: 
Higgins et al., 2013, Malar J