E-selectin (ELAM-1, CD62E)

Molecular group: 
Adhesion molecules
Molecule/Cell: 
E-selectin (ELAM-1, CD62E)
Plasmodium strain: 
Plasmodium falciparum
Organ: 
Brain (PM)-IHC
Population: 
Ghana
Transmission: 
Stable
Adult/Pediatric: 
Pediatric
CM vs NCSM: 
=
CM vs NM-NCNS: 
Patient number: 
21
Additional differences: 
+ correlation with sequestration of pRBC; only vascular staining; receptor staining also in vessels without pRBC sequestration → receptor upregulation is not solely the result of pRBC binding to a specific EC, but more likely the result of systemically produced soluble mediators; also pRBC sequestration without receptor expression; the only NM patient to show E-selectin staining was the child that died of Salmonella septicaemia (< fatal malaria) ; receptor staining and pRBC sequestration in cerebellum > receptor staining and pRBC sequestration in cerebrum and brainstem
Refs: 
Armah et al., 2005, Ann Trop Med Parasitol