Molecular group:
Adhesion molecules
Molecule/Cell:
E-selectin (ELAM-1, CD62E)
Plasmodium strain:
Plasmodium falciparum
Organ:
Brain (PM)-IHC
Population:
Ghana
Transmission:
Stable
Adult/Pediatric:
Pediatric
CM vs NCSM:
=
CM vs NM-NCNS:
>
Patient number:
21
Additional differences:
+ correlation with sequestration of pRBC; only vascular staining; receptor staining also in vessels without pRBC sequestration → receptor upregulation is not solely the result of pRBC binding to a specific EC, but more likely the result of systemically produced soluble mediators; also pRBC sequestration without receptor expression; the only NM patient to show E-selectin staining was the child that died of Salmonella septicaemia (< fatal malaria) ; receptor staining and pRBC sequestration in cerebellum > receptor staining and pRBC sequestration in cerebrum and brainstem
Refs:
Armah et al., 2005, Ann Trop Med Parasitol
Hyperlink: