Molecular group:
Metabolic markers
Molecule/Cell:
Cysteamine (CysH)
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
+ cysteamine hydrochloride (prophylactic treatment)
Lethal infection (Con):
yes (100%)
Lethal infection (EG):
yes (20%)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased
Additional phenotypes (EG vs Con):
Dose-dependent antimalarial effect; dose-dependent effect on survival
Refs:
Min-Oo et al., 2010, Exp Parasitol
Hyperlink: