Molecular group:
Metabolic markers
Molecule/Cell:
Cysteamine (CysH)
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6 - 10^7
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
+ cysteamine hydrochloride + a suboptimal dose of artesunate or dihydroartemisinin
Lethal infection (Con):
yes
Lethal infection (EG):
No
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased
Additional phenotypes (EG vs Con):
Dose-dependent synergistic antimalarial effect; dose-dependent effect on survival; ↓ disease symptoms
Refs:
Min-Oo et al., 2010, Antimicrob Agents Chemother
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