Cysteamine (CysH)

Molecular group: 
Metabolic markers
Molecule/Cell: 
Cysteamine (CysH)
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^6 - 10^7
Mouse genetic background (Con): 
A/J
Experimental treatment group (EG): 
+ cysteamine hydrochloride + a suboptimal dose of artesunate or dihydroartemisinin
Lethal infection (Con): 
yes
Lethal infection (EG): 
No
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Delayed onset and decreased
Additional phenotypes (EG vs Con): 
Dose-dependent synergistic antimalarial effect; dose-dependent effect on survival; ↓ disease symptoms
Refs: 
Min-Oo et al., 2010, Antimicrob Agents Chemother