Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

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Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
IL-4 Plasmodium yoelii 17XL BALB/cCr → Ishih et al., 2004, Parasitol Res Link
IL-4 Plasmodium yoelii 17XNL (BALB/c x C57BL/6) F1 ↑d5-21 De Souza et al., 1997, Infect Immun Link
IL-4 Plasmodium yoelii 265 BALB/c → Singh et al., 2002, J Immunol Link
IL-5 Plasmodium berghei ANKA C57BL/6 ↑d7 ↑d5 Beghdadi et al., 2008, J Exp Med Link
IL-6 Plasmodium berghei ANKA 129Sv/Ev → ↑d7 Amani et al., 2000, Eur J Immunol Link
IL-6 Plasmodium berghei ANKA BALB/c ↑d7 → De Kossodo et al., 1993, J Immunol Link
IL-6 Plasmodium berghei ANKA C57BL/6 ↑d4 Van der Heyde et al., 2005, Blood Link
IL-6 Plasmodium berghei ANKA C57BL/6 ↑d5 Beghdadi et al., 2008, J Exp Med Link
IL-6 Plasmodium berghei ANKA C57BL/6 ↑d5 Randall et al., 2008, Infect Immun Link
IL-6 Plasmodium berghei ANKA C57BL/6 ↑d10 Labbé et al., 2010, J Immunol Link
IL-6 Plasmodium berghei ANKA CBA ↑d5 Randall et al., 2008, Infect Immun Link
IL-6 Plasmodium berghei ANKA CBA/Ca ↑d7 Grau et al., 1990, J Exp Med Link
IL-6 Plasmodium berghei ANKA CBA/J ↑d7 → De Kossodo et al., 1993, J Immunol Link
IL-6 Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 → ↑d8 Delic et al., 2010, Infect Immun Link
IL-6 Plasmodium yoelii 17XNL CBA/Ca ↑d7 Grau et al., 1990, J Exp Med Link
Indoleamine 2,3-dioxygenase (IDO) Plasmodium berghei ANKA C57BL/6 ↑d6 Mitchell et al., 2005, Infect Immun Link
Indoleamine 2,3-dioxygenase (IDO) Plasmodium berghei ANKA + K173 C57BL/6 ↑d1 Mitchell et al., 2005, Infect Immun Link
Indoleamine 2,3-dioxygenase (IDO) Plasmodium berghei K173 C57BL/6 ↑d1, d6 ↑d1 Mitchell et al., 2005, Infect Immun Link
Indoleamine 2,3-dioxygenase-1 (IDO-1) Plasmodium berghei ANKA CBA/T6 ↑d7 ↑d7 ↑d6 ↑d7 ↑d7 Hansen et al., 2004, Int J Parasitol Link
Indoleamine 2,3-dioxygenase-1 (IDO-1) Plasmodium berghei ANKA CBA/T6 A ↑d6-7 A ↑d6-7 →/A ↑d6-7 Sanni et al., 1998, Am J Pathol Link
Indoleamine 2,3-dioxygenase-1 (IDO-1) Plasmodium berghei K173 CBA/T6 ↑d14 ↑d14 ↑d14 ↑d14 ↑d14 Hansen et al., 2004, Int J Parasitol Link
Indoleamine 2,3-dioxygenase-1 (IDO-1) Plasmodium berghei K173 CBA/T6 A → A ↑d6-7, d14-15 ↑d14-15/A ↑d14-15 Sanni et al., 1998, Am J Pathol Link
JNK1/2 Plasmodium berghei ANKA C57BL/6J → Anand et al., 2011, Neurosci Lett Link
Kynurenic acid (KA) Plasmodium berghei ANKA C57BL/6J → Clark et al., 2005, Infect Immun Link
Kynurenic acid (KA) Plasmodium berghei ANKA C57BL/6J → Miu et al., 2009, Int J Parasitol Link
Kynurenic acid (KA) Plasmodium berghei ANKA CBA/T6 ↑d6-7 Sanni et al., 1998, Am J Pathol Link
Kynurenic acid (KA) Plasmodium berghei K173 CBA/T6 ↑d13-17 Sanni et al., 1998, Am J Pathol Link
Kynurenine (Kyn) Plasmodium berghei ANKA CBA/T6 ↑d6-7 ↑d6-7 ↑d6-7 Sanni et al., 1998, Am J Pathol Link
Kynurenine (Kyn) Plasmodium berghei K173 CBA/T6 ↑d14-15 ↑d6-7, d14-15 ↑d6-7, d14-15 Sanni et al., 1998, Am J Pathol Link
Lactate Plasmodium berghei ANKA C57BL/6 ↑d4-6 Chang et al., 2001, Infect Immun Link
Lactate Plasmodium berghei ANKA C57BL/6 → Parekh et al., 2006, Int J Parasitol Link
Lactate Plasmodium chabaudi adami 408XZ C57BL/6 ↑d10-16 Hernandez-Valladares et al., 2006, Exp Parasitol Link
Leukotriene B4 Plasmodium berghei ANKA ICR ↑d7 Xiao et al., 1999, Am J Trop Med Hyg Link
LIGHT Plasmodium berghei ANKA C57BL/6 ↓d3-6 ↑d6 Randall et al., 2008, J Immunol Link
LT-a Plasmodium berghei ANKA C57BL/6 ↑d7 Engwerda et al., 2002, J Exp Med Link
LT-a Plasmodium berghei ANKA C57BL/6 ↑d6 Miu et al., 2008, J Immunol Link
LT-a Plasmodium berghei ANKA C57BL/6 ↑d6 Pamplona et al., 2007, Nat Med Link
LT-a Plasmodium berghei ANKA C57BL/6 ↑d6 Randall et al., 2008, Infect Immun Link
LT-a Plasmodium berghei ANKA C57BL/6 → Wiese et al., 2008, Malar J Link
LT-a Plasmodium berghei ANKA CBA ↑d6 Randall et al., 2008, Infect Immun Link
LT-a Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
LT-a Plasmodium berghei K173 CBA/T6 ↑d14 Rae et al., 2004, FASEB J Link
LT-b Plasmodium berghei ANKA C57BL/6 ↑d6 Randall et al., 2008, Infect Immun Link
LT-b Plasmodium berghei ANKA CBA ↑d6 Randall et al., 2008, Infect Immun Link
LT-b Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
LT-b Plasmodium berghei K173 CBA/T6 ns Rae et al., 2004, FASEB J Link
LT-bR Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
LT-bR Plasmodium berghei K173 CBA/T6 ns Rae et al., 2004, FASEB J Link
m-calpain Plasmodium berghei ANKA Swiss ↓d16 Shukla et al., 2006, Neurochem Int Link
MadCAM-1 Plasmodium berghei ANKA C57BL/6 → → → ↑d6 Li et al., 2003, J Investig Med Link
MHC-I Plasmodium berghei ANKA C57BL/6 → ↑d6 Potter et al., 2006, Int J Parasitol Link
MHC-I Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, Int J Parasitol Link
MIF Plasmodium berghei NK65 C57BL/6J ↑d10 Van den steen et al., 2010, Am J Respir Crit Care Med Link
MIG Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
MIG Plasmodium chabaudi chabaudi AS C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
MMP-11 Plasmodium berghei ANKA BALB/c → Van den steen et al., 2006, Lab Invest Link
MMP-11 Plasmodium berghei ANKA C57BL/6 ND ND → ↓d6-8 ↓d6-8 Van den steen et al., 2006, Lab Invest Link
MMP-11 Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
MMP-12 Plasmodium berghei ANKA BALB/c → Van den steen et al., 2006, Lab Invest Link
MMP-12 Plasmodium berghei ANKA C57BL/6 ND ↑d6 ↓d8 ND ND Van den steen et al., 2006, Lab Invest Link
MMP-12 Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
MMP-13 Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2006, Lab Invest Link
MMP-13 Plasmodium berghei ANKA C57BL/6 ↑d6 ↑d6 ↑d6-8 ND ND Van den steen et al., 2006, Lab Invest Link
MMP-13 Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
MMP-2 (Gelatinase A) Plasmodium berghei ANKA BALB/c → Van den steen et al., 2006, Lab Invest Link
MMP-2 (Gelatinase A) Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
MMP-3 Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2006, Lab Invest Link
MMP-3 Plasmodium berghei ANKA C57BL/6 ↑d6-8 ND ↑d8 → ND Van den steen et al., 2006, Lab Invest Link
MMP-3 Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2006, Lab Invest Link
MMP-7 Plasmodium berghei ANKA C57BL/6 ND ↑d6-8 ND ND ND Van den steen et al., 2006, Lab Invest Link
MMP-8 Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2006, Lab Invest Link
MMP-8 Plasmodium berghei ANKA C57BL/6 ↑d6-8 ↑d6-8 ↑d6-8 ↑d6-8 ND Van den steen et al., 2006, Lab Invest Link
MMP-8 Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2006, Lab Invest Link
MMP-9 (Gelatinase B) Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2006, Lab Invest Link
MMP-9 (Gelatinase B) Plasmodium berghei ANKA C57BL/6 ↓d4-8 → ↑d8 → ND Van den steen et al., 2006, Lab Invest Link
MMP-9 (Gelatinase B) Plasmodium berghei ANKA C57BL/6 ↑d6 Gramaglia et al., 2006, Nat Med Link
MMP-9 (Gelatinase B) Plasmodium berghei NK65 C57BL/6 ↑d6-8 ↑d8 ↑d8 ↑d8 Van den steen et al., 2006, Lab Invest Link
Monocarboxylate transporter 2 (MCT2) Plasmodium berghei ANKA CBA/T6 → Rae et al., 2004, FASEB J Link
Monocarboxylate transporter 2 (MCT2) Plasmodium berghei K173 CBA/T6 ↑d2-9 Rae et al., 2004, FASEB J Link
MRP4 Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 → Delic et al., 2010, Infect Immun Link
MT1-MMP Plasmodium berghei ANKA C57BL/6 ↑d6-8 ↑d6-8 ↑d6-8 Van den steen et al., 2006, Lab Invest Link
MT2-MMP Plasmodium berghei ANKA C57BL/6 ND ↓d6-8 ↓d8 Van den steen et al., 2006, Lab Invest Link
MT3-MMP Plasmodium berghei ANKA C57BL/6 ND ND ND ND Van den steen et al., 2006, Lab Invest Link
MT4-MMP Plasmodium berghei ANKA C57BL/6 ND ND ND ND Van den steen et al., 2006, Lab Invest Link
MT5-MMP Plasmodium berghei ANKA C57BL/6 ND ND ND ND Van den steen et al., 2006, Lab Invest Link
NF-kB Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 → Delic et al., 2010, Infect Immun Link
NO Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 Delic et al., 2010, Infect Immun Link
NO Plasmodium chabaudi chabaudi AS C57BL/6 ↑d8 Su et al., 2002, J Immunol Link
NO2- Plasmodium berghei ANKA C57BL/6 ↓d6 Gramaglia et al., 2006, Nat Med Link
NO2- Plasmodium berghei ANKA C57BL/6 ↑d8-11 Tan et al., 1999, Infect Immun Link
NO3- Plasmodium chabaudi chabaudi AS 129/Sv/Ev x C57BL/6 ns Favre et al., 1997, Parasite Immunol Link
NO3- Plasmodium chabaudi chabaudi AS A/J → Stevenson et al., 1995, J Immunol Link
NO3- Plasmodium chabaudi chabaudi AS C57BL/6 ↑d7 Su et al., 2000, Infect Immun Link
NO3- Plasmodium chabaudi chabaudi AS C57BL/6 ↑d12 Favre et al., 1999, Parasitology Link
NO3- Plasmodium chabaudi chabaudi AS C57BL/6 ↑d7 Jacobs et al., 1996, Infect Immun Link
Noradrenaline (NA) Plasmodium berghei (N.I.) Albino ↓d N.I. (40-50% par) Roy et al., 1993, Indian J Malariol Link
NOS2 (iNOS) Plasmodium berghei ANKA C57BL/6 → ↑d4-8 ↑d8 → Tan et al., 1999, Infect Immun Link
NOS2 (iNOS) Plasmodium berghei NK65 C57BL/6 ↑d6 ↑d4-8 Yoshimoto et al., 1998, J Immunol Link
NOS2 (iNOS) Plasmodium berghei XAT CBA/JNCrj ↑d6 Yoshimoto et al., 1998, J Infect Dis Link
NOS2 (iNOS) Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 Delic et al., 2010, Infect Immun Link

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