Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

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Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
Cleaved a-spectrin (SBDP150) Plasmodium berghei ANKA Swiss ↑d16 Shukla et al., 2006, Neurochem Int Link
Cleaved pro-caspase-3 (in platelets) Plasmodium berghei ANKA C57BL/6 ↑d8 Piguet et al., 2002, Apoptosis Link
COX-1 Plasmodium berghei ANKA CBA ↑d6 Ball et al., 2004, J Infect Dis Link
COX-1 Plasmodium berghei ANKA ICR → ↑d7 Xiao et al., 1999, Am J Trop Med Hyg Link
COX-1 Plasmodium berghei K173 CBA ↑d14 Ball et al., 2004, J Infect Dis Link
COX-2 Plasmodium berghei ANKA CBA ↑d3-6 Ball et al., 2004, J Infect Dis Link
COX-2 Plasmodium berghei ANKA ICR → ↑d7 Xiao et al., 1999, Am J Trop Med Hyg Link
COX-2 Plasmodium berghei K173 CBA → Ball et al., 2004, J Infect Dis Link
CX3CL1 (neurotactin) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CX3CL1 (neurotactin) Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CX3CR1 Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CX3CR1 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL1 (GRO-a, KC) Plasmodium berghei ANKA C57BL/6 ↑d5 Beghdadi et al., 2008, J Exp Med Link
CXCL1 (GRO-a, KC) Plasmodium berghei ANKA C57BL/6 ↑d5-6 Finney et al., 2009, Am J Trop Med Hyg Link
CXCL1 (GRO-a, KC) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CXCL1 (GRO-a, KC) Plasmodium berghei K173 CBA/T6 ↑d14 Miu et al., 2008, J Immunol Link
CXCL1 (GRO-a, KC) Plasmodium berghei NK65 C57BL/6J ↑d10-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL1 (GRO-a, KC) Plasmodium chabaudi chabaudi AS C57BL/6J → Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL10 (IP-10) Plasmodium berghei ANKA BALB/c ↑d7 Hansen et al., 2005, Infect Immun Link
CXCL10 (IP-10) Plasmodium berghei ANKA BALB/c → ↑d1, d6-8 ↑d1-8 Hanum et al., 2003, Int Immunol Link
CXCL10 (IP-10) Plasmodium berghei ANKA BALB/c ↑d8 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL10 (IP-10) Plasmodium berghei ANKA C57BL/6 ↑d6 ↑d6 ↑d6-8 ↑d6-8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CXCL10 (IP-10) Plasmodium berghei ANKA C57BL/6 → ↑d1 ↑d1-8 Hanum et al., 2003, Int Immunol Link
CXCL10 (IP-10) Plasmodium berghei ANKA C57BL/6 ↑d6 Miu et al., 2008, J Immunol Link
CXCL10 (IP-10) Plasmodium berghei ANKA C57BL/6 ↑d6-8 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL10 (IP-10) Plasmodium berghei ANKA C57BL/6J ↑d5 ↑d5 ↑d5 Morrell et al., 2011, Infect Immun Link
CXCL10 (IP-10) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CXCL10 (IP-10) Plasmodium berghei ANKA DBA/1 ↑d10 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL10 (IP-10) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL10 (IP-10) Plasmodium berghei K173 CBA/T6 ↑d6, d14 Miu et al., 2008, J Immunol Link
CXCL10 (IP-10) Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL10 (IP-10) Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL10 (IP-10) Plasmodium chabaudi chabaudi AS C57BL/6J ↑d8 Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL11 (I-TAC) Plasmodium berghei ANKA BALB/c ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CXCL11 (I-TAC) Plasmodium berghei ANKA C57BL/6 → ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CXCL11 (I-TAC) Plasmodium berghei ANKA C57BL/6 → ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CXCL11 (I-TAC) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CXCL11 (I-TAC) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CXCL11 (I-TAC) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL11 (I-TAC) Plasmodium berghei K173 CBA/T6 ↑d6, d14 Miu et al., 2008, J Immunol Link
CXCL11 (I-TAC) Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL11 (I-TAC) Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL11 (I-TAC) Plasmodium chabaudi chabaudi AS C57BL/6J ↑d8 Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL12 (SDF-1) Plasmodium berghei ANKA C57BL/6 ↓d8 ↓d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CXCL12 (SDF-1) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL12a (SDF-1a) Plasmodium berghei ANKA BALB/c ↓d6-8 Van den steen et al., 2008, Eur J Immunol Link
CXCL12a (SDF-1a) Plasmodium berghei ANKA C57BL/6 ↓d6-8 Van den steen et al., 2008, Eur J Immunol Link
CXCL13 (BCL, BCA-1) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CXCL13 (BCL, BCA-1) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL14 (BRAK) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL14 (BRAK) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL16 Plasmodium berghei ANKA C57BL/6 ↓d8 ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CXCL16 Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL16 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL2 (GRO-b, MIP-2) Plasmodium berghei ANKA C57BL/6 ↑d8 ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CXCL2 (GRO-b, MIP-2) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CXCL2 (GRO-b, MIP-2) Plasmodium berghei K173 CBA/T6 ↑d6,d 14 Miu et al., 2008, J Immunol Link
CXCL2 (GRO-b, MIP-2) Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL2 (GRO-b, MIP-2) Plasmodium chabaudi chabaudi AS C57BL/6J → Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL4 (PF-4) Plasmodium berghei ANKA C57BL/6J ↑d5 ↑d4-6 Srivastava et al., 2008, Cell Host Microbe Link
CXCL4 (PF-4) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL4 (PF-4) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL5 (ENA-78) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL5 (ENA-78) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL6 (mGCP-2, LIX) Plasmodium berghei ANKA BALB/c → Van den steen et al., 2008, Eur J Immunol Link
CXCL6 (mGCP-2, LIX) Plasmodium berghei ANKA C57BL/6 → → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CXCL6 (mGCP-2, LIX) Plasmodium berghei ANKA C57BL/6 → Van den steen et al., 2008, Eur J Immunol Link
CXCL6 (mGCP-2, LIX) Plasmodium berghei NK65 C57BL/6J → Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL6 (mGCP-2, LIX) Plasmodium chabaudi chabaudi AS C57BL/6J → Van den steen et al., 2010, Am J Respir Crit Care Med Link
CXCL7 (NAP-2) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL7 (NAP-2) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCL9 (MIG) Plasmodium berghei ANKA BALB/c ↑d7 Hansen et al., 2005, Infect Immun Link
CXCL9 (MIG) Plasmodium berghei ANKA BALB/c ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CXCL9 (MIG) Plasmodium berghei ANKA C57BL/6 ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CXCL9 (MIG) Plasmodium berghei ANKA C57BL/6J ↑d5 ↑d5 ↑d5 Morrell et al., 2011, Infect Immun Link
CXCL9 (MIG) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CXCL9 (MIG) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CXCL9 (MIG) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCL9 (MIG) Plasmodium berghei K173 CBA/T6 ↑d6, d14 Miu et al., 2008, J Immunol Link
CXCL9 (MIG) Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CXCR2,4,5,6 Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CXCR2,4,5,6 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CXCR3 Plasmodium berghei ANKA C57BL/6J ↑d6 Morrell et al., 2011, Infect Immun Link
CXCR3 Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CXCR3 Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CYP3A11 Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ns Delic et al., 2010, Infect Immun Link
CYP7A1 Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 Delic et al., 2010, Infect Immun Link
Cytochrome-c (cytosol) Plasmodium berghei ANKA Swiss ↑d14-16 Kumar et al., 2002, Neurosci Lett Link
Cytochrome-c (membrane) Plasmodium berghei ANKA Swiss ↓d14-16 Kumar et al., 2002, Neurosci Lett Link
DARC (FY, CD234) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
DARC (FY, CD234) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
dityrosine Plasmodium berghei ANKA CBA/T6 → Sanni et al., 1999, J Infect Dis Link
dityrosine Plasmodium berghei K173 CBA/T6 ↓d15 Sanni et al., 1999, J Infect Dis Link
DOPA Plasmodium berghei ANKA CBA/T6 → Sanni et al., 1999, J Infect Dis Link
DOPA Plasmodium berghei K173 CBA/T6 ↓d15 Sanni et al., 1999, J Infect Dis Link
Dopamine (DA) Plasmodium berghei (N.I.) Albino → Roy et al., 1993, Indian J Malariol Link
Endothelin receptor A (ETA) Plasmodium berghei ANKA C57BL/6 ↑d5 Machado et al., 2006, Exp Biol Med (Maywood) Link
Endothelin receptor B (ETB) Plasmodium berghei ANKA C57BL/6 ↑d5 Machado et al., 2006, Exp Biol Med (Maywood) Link
Endothelin-1 (Et-1) Plasmodium berghei ANKA C57BL/6 ↑d5 Machado et al., 2006, Exp Biol Med (Maywood) Link
Endothelin-converting enzyme (ECE) Plasmodium berghei ANKA C57BL/6 ↑d5 Machado et al., 2006, Exp Biol Med (Maywood) Link

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